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KMID : 1102220160350020078
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Kidney Research and Clinical Practice
2016 Volume.35 No. 2 p.78 ~ p.83
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Changes in urinary potassium excretion in patients with chronic kidney disease
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Ueda Yuichiro
Ookawara Susumu
Ito Kiyonori
Miyazawa Haruhisa
Kaku Yoshio
Hoshino Taro
Tabei Kaoru
Morishita Yoshiyuki
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Abstract
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Background: Hyperkalemia is one of the more serious complications of chronic kidney disease (CKD), and the cause of potassium retention is a reduction in urinary potassium excretion. However, few studies have examined the extent of the decrease of urinary potassium excretion in detail with respect to decreased renal function.
Methods: Nine hundred eighty-nine patients with CKD (CKD stages G1 and G2 combined: 135; G3a: 107; G3b: 170; G4: 289; and G5: 288) were evaluated retrospectively. Values for urinary potassium excretion were compared between CKD stages, and the associations between urinary potassium excretion and clinical parameters, including diabetes mellitus?status and use of renin?angiotensin?aldosterone system?inhibitors, were analyzed using a multivariable linear regression analysis.
Results: Urinary potassium excretion gradually decreased with worsening of CKD (G5: 24.8?±?0.8?mEq/d, P?P?
Conclusion: This study demonstrated that urinary potassium excretion decreased with reductions in renal function. Furthermore, urinary potassium excretion was mainly affected by urinary sodium excretion and estimated glomerular filtration rate in patients with CKD, whereas the presence of diabetes mellitus and use of renin?angiotensin?aldosterone ystem inhibitors were not associated with urinary potassium excretion in this study.
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KEYWORD
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Chronic kidney disease, Estimated glomerular filtration rate, Urinary potassium excretion
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